The German-Baltic Chamber of Commerce AHK, the Lithuanian engineering industries association LINPRA and the Information and Communication Technologies Association INFOBALT hosted the 4th international Industry 4.0 Conference under the motto Making Industry 4.0 real. Aiming to meet the industry’s need to deepen and share the best business practices and experiences related to transformation, the conference mostly focussed on the practical side. Most of the presentations introduced real examples from companies’ activities and business solutions: what challenges and transformations they faced, how much investments they needed, and what returns are already gained or expected in the future by those, who adapt and keep pace with the development of the Fourth Industrial Revolution. The conference also offered insights of the European leaders in this field, such as Germany, and hosted experts from German, Latvian and Estonian public sectors, government representatives and industry.